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Select Search Criteria 1 Date Range All Dates Single Year  199019911992199319941995199619971998199920002001200220032004200520062007200820092010 From  199019911992199319941995199619971998199920002001200220032004200520062007200820092010 to Present From  199019911992199319941995199619971998199920002001200220032004200520062007200820092010 to 199019911992199319941995199619971998199920002001200220032004200520062007200820092010 2 Company Code All Companies Single Company 3 Study Code 4 Species & Strain/Stock Rat  Crl:CD(SD)IGS BRCrl:CD(SD)BRCrl:(WI)BRCrl:(LE)BRCrl:(ZUC)-faBRHsd:Sprague Dawley SDHsd:Sprague Dawley (CD)HsdBrl:WHHsdCpb:WUF344/NHsdSAS:VAF (SD)F-344/SASTac:N(SD)fBRTac:Glx:WIfBRTac:N(WKY)fBR Mouse  Crl:CD-1 (ICR) BRCrl:CF-1 BRCrl:CFW (SW) BRHsd:ICR(CD-1)B6C3F1/HsdTac:(SW)fBRTac:Icr:Ha(ICR)fBRTac:N:NIHS-BCfBRSAS/CF-1 Rabbit  Crl:KBL(NZW)BRHra:(NZW)SPFHaz:(NZW)fBRHaz:(DB)SPFHsdPoc:DutchHsdIf:NZWHsdPoc:NZWHsdRivm:ELCO Other  GerbilGuinea PigHamsterMonkey Crl:(MON)BRCrl:(HA)BRCrl:IAF(HA)-hrBRLak:LVG(SYR)BRSAS (E)/GSHMacaca mulatta (rhesus)Macaca fascicularis (cynomolgus)Papio cynocephalus (baboon) 5 Source Company Charles River LaboratoriesCovanceHarlanSASCO (Stone Ridge, NY)Taconic 6 Source Country BelgiumCanadaFranceGermanyHungaryIsraelItalyJapanNetherlandsSpainSwedenUnited KingdomUnited States 7 Source City Atsugi, JapanBarcelona, SpainBicester, UKBorchen, GermanyBrussels, BelgiumBudapest, HungaryCalco, ItalyDenver, PADublin, VAEin Karem, IsraelFredrick, MDGannat, FranceGermantown, NYHino, JapanHollister, CAHorst, the NetherlandsHouston, TXHuntingdon, UKIndianapolis, INKalamazoo, MIKisslegg, GermanyL'Arbresle Cedex, FranceMadison, WIMargate, UKPortage, MIPrattville, ALRehovot, IsraelRaleigh, NCSan Diego, CASomeren, the NetherlandsSt. Aubin-les-Elbeuf, FranceSt. Constant, QuebecStone Ridge, NY (CR Kingston)Sulzfeld, GermanyTsukuba, JapanUdine, ItalyUppsala, SwedenWilmington, MA 8 Route UntreatedOral gavageInhalation, whole-bodyInhalation, nose-onlyIntravenous injection - bolusIntravenous injection - continuousIntramuscularIntraperitoneal injectionSubcutaneous injectionDermal application, non-occludedDermal application, occulded 9 Vehicle None (includes ground diet)Water (includes all types)0.1-0.5% Methylcellulose (MC) in water0.51-2.0% Methylcellulose (MC) in water0.5% MC + 0.1-0.5% Tween 800.5% MC + 0.02% Na lauryl sulfate (SLS)0.1-0.5% Carboxymethylcellulose (CMC)0.51-2.0% CMC0.5% CMC + 0.1-0.5% Tween 800.5% Hydroxypropylmethylcellulose (HPMC)0.5% HPMC + 0.1-0.5% Tween 801-2% Avicel1-3% Gum tragacanth< 3% Corn starch< 3% Corn starch + 0.1-0.5% Tween 80< 15% Polyethylene glycol 300 or 40025% Cremaphor ELSaline (e.g., 0.9% NaCl, PBS)< 50% Ethenol in water< 3.5% Mannitol in water< 5% Dextrose in water< 10% Tween 80 in water/saline/bufferCottonseed oilOlive oilPeanut oilRapeseed oilSesame oilSoybean oil 10 Dose Volume (ml/kg) All Volumes Single Volume  Range from  to 11 Parental Generation F0F1F2 12 Age of Females on GD 0 (weeks) Gestation Day 0 = day of plug/sperm All Ages Range from  to 13 Days Treated prior to GD 0 14 First Gestation Day of Treatment 15 Last Gestation Day of Treatment 16 First Lactation Day of Treatment 17 Last Lactation Day of Treatment

Select Display Options Females assigned to a group Nulliparous only. Gestation length Mated females Percent mated females Pregnant females Percent pregnant of mated females   Percent pregnant of total females Females with all resorptions/dead fetuses Percent females with all resorptions/dead fetuses Females unable to deliver by GD 24 Percent females unable to deliver by GD 24 Females with all dead/cannibalized pups at birth Percent females with all dead/cannibalized pups at birth Females with live pups at birth PND of culling PND = Postnatal day. Pups per litter after culling Implantation sites per litter Percent post-implantation loss per litter [(dead + missing + cannibalized pups on PND 0)/implantation sites] x 100 Percent post-implantation survival per litter Live pups per litter at birth Sex ratio at birth (% males) Percent pup survival on PND 0 Percent pup survival on PND 0-4 Percent pup survival on PND 0-21 Percent pup survival on PND 4-21 D/M/C pups per litter on PND 0 D/M/C = Dead, missing, or cannibalized. D/M/C pups per litter on PND 1 D/M/C pups per litter on PND 4 D/M/C pups per litter on PND 7 D/M/C pups per litter on PND 14 D/M/C pups per litter on PND 21 D/M/C pups per litter on PND 0/1-4 Prior to culling. D/M/C pups per litter on PND 4-7 Post culling. D/M/C pups per litter on PND 7-14 D/M/C pups per litter on PND 14-21 Live combined pup weight at birth (grams) D/M/C pups per litter on PND 4-21 Live male pup weight at birth (grams) Live female pup weight at birth (grams) Live combined pup weight PND 7 (grams) Live male pup weight PND 7 (grams) Live combined pup weight PND 14 (grams) Live female pup weight PND 7 (grams) Live male pup weight PND 14 (grams) Live female pup weight PND 14 (grams) Live combined pup weight PND 21 (grams) Live male pup weight PND 21 (grams)   Live female pup weight PND 21 (grams) PND 0 male anogenital distance (mm) PND 0 female anogenital distance (mm) PND 21 male anogenital distance (mm) PND 21 female anogenital distance (mm)